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Mast Cell Activation Syndrome

Question for Department of Health and Social Care

UIN 129388, tabled on 23 February 2018

To ask the Secretary of State for Health and Social Care, if his Department will include Mast Cell Activation Syndrome (MCAS) in the 100K genome project and establish links to the MCAS Research Centre at the University of Bonn Institute of Genetics.

Answered on

5 March 2018

Mast Cell Activation Syndrome (MCAS) does not currently have a specific disease category within the 100,000 Genomes Project but patients with MCAS in the context of other medical disorders or congenital malformations suggestive of a genetic cause are eligible. In addition, a proposal for inclusion of familial MCAS in the project is currently under peer review and will be considered by the Genomics England Science Advisory Committee at their next meeting.

Genomics England will seek to establish links between the relevant Genomics England Clinical Interpretation Partnership (GeCIP) domains and the MCAS Research Centre at the University Of Bonn Institute Of Genetics.

More about GeCIP can be found here:

https://www.genomicsengland.co.uk/about-gecip/